GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE295nnn/GSE295693/primaryOK200GenomicsHomo sapiensNon-coding RNA profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE295693GEOGSEfalseSmall RNA sequencing of extracellular vesicles extracted from adipose tissue of healthy weight or obese human subjectsWe identified EVs as novel regulatory factors that mediate adipose tissue–brain communication and are crucial for the central control of whole-body energy homeostasis. Our findings reveal that AT-EVs and their cargo microRNAs (miRNAs) are crucial regulators of central leptin sensitivity. To identify the specific subtypes of miRNAs that responsible for central leptin-sensitizing, we examined the sRNA profiles of EVs extracted from adipose tissue of healthy weight and obese subjects by RNA deep sequencing.2026/04/10GSE295693GSM8955296GSM8955295GSM8955298GSM8955297GSM8955300GSM8955299GSM895530116791295693Homo sapiens[41223857]