{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE295nnn/GSE295694/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Non-coding RNA profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE295694"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Small RNA sequencing of adipose tissue derived extracellular vesicles from chow- or HFD-fed male mice","description":"We identified EVs as novel regulatory factors that mediate adipose tissue–brain communication and are crucial for the central control of whole-body energy homeostasis. Our findings reveal that AT-EVs and their cargo microRNAs (miRNAs) are crucial regulators of central leptin sensitivity. To identify the specific subtypes of miRNAs that responsible for central leptin-sensitizing, we examined the sRNA profiles of EVs extracted from adipose tissue of healthy chow-fed and high-fat diet mice by RNA deep sequencing.","dates":{"publication":"2026/04/10"},"accession":"GSE295694","cross_references":{"GSM":["GSM8955308","GSM8955307","GSM8955304","GSM8955303","GSM8955306","GSM8955305","GSM8955302"],"GPL":["17021"],"GSE":["295694"],"taxon":["Mus musculus"],"PMID":["[41223857]"]}}