GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE295nnn/GSE295694/primaryOK200GenomicsMus musculusNon-coding RNA profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE295694GEOGSEfalseSmall RNA sequencing of adipose tissue derived extracellular vesicles from chow- or HFD-fed male miceWe identified EVs as novel regulatory factors that mediate adipose tissue–brain communication and are crucial for the central control of whole-body energy homeostasis. Our findings reveal that AT-EVs and their cargo microRNAs (miRNAs) are crucial regulators of central leptin sensitivity. To identify the specific subtypes of miRNAs that responsible for central leptin-sensitizing, we examined the sRNA profiles of EVs extracted from adipose tissue of healthy chow-fed and high-fat diet mice by RNA deep sequencing.2026/04/10GSE295694GSM8955308GSM8955307GSM8955304GSM8955303GSM8955306GSM8955305GSM895530217021295694Mus musculus[41223857]