GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE295nnn/GSE295978/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE295978GEOGSEfalseDifferentially expressed genes by YAP-mediated RPE repair in mouse after sodium iodate injuryDamage or degeneration results in RPE atrophy such as in AMD, the leading cause of blindness in the elderly population. In contrast to other epithelial tissues, the mature RPE is postmitotic and does not renew itself. Using sodium iodate (SI) as an injury model in mouse, we have previously shown that genetic overexpression of the Hippo pathway effector Yap (YOE) significantly improves a- and b-wave ERG amplitudes and RPE tissue and cellular integrity 7 days post injury. To elucidate the molecular and cellular mechanisms of RPE repair by YOE, we conducted bulk RNAseq for identifying differentially expressed genes (DEGs).2026/05/01GSE295978GSM8962778GSM8962767GSM8962779GSM8962768GSM8962776GSM8962765GSM8962766GSM8962777GSM8962769GSM8962781GSM8962770GSM8962782GSM8962771GSM8962780GSM8962774GSM8962763GSM8962775GSM8962764GSM8962772GSM8962783GSM896277334290295978Mus musculus