GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE296nnn/GSE296131/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296131GEOGSEfalseStage-specific degradation of cyclin D3 orchestrates myelopoiesis and restrains MPN development [RNA-seq]Cyclin D3 is critical for myelopoiesis, with its rapid, stage-specific degradation regulating normal granulocyte-monocyte differentiation. Using a knock-in mouse model with a degradation-resistant cyclin D3 variant (D3T283A), we show that sustained cyclin D3 levels enhance granulocyte-monocyte output, cause microcytic erythrocytes, thrombocytosis, and extramedullary hematopoiesis. Splenic HSPCs from D3T283A mice exhibit increased self-renewal and competitive repopulation advantage. Prolonged D3T283A expression drives a high-penetrance myeloproliferative neoplasm, reducing survival.2026/05/01GSE296131GSM8965594GSM8965593GSM8965592GSM8965591GSM8965596GSM896559534328296131Mus musculus