GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE296nnn/GSE296247/primaryOK200TranscriptomicsMycobacterium tuberculosisExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296247GEOGSEfalseEffect of medium pH on the transcriptomes of Mycobacterium tuberculosis H37Rv parental, Δrv0998 and rv0998 complemented strainsMycobacterium tuberculosis (Mtb) survives host defenses by adapting to the environmental conditions during infection. A critical survival strategy involves pH homeostasis, mediated by complex signalling systems that regulate metabolic reprogramming and stress responses. While the lysine acetyltransferase Rv0998 is known to support Mtb hypoxia adaptation and metabolic flexibility, its role in acid stress remains unexplored. Here, we investigate how Rv0998 enables acid tolerance by analysing the transcriptomic profiles of the strains under physiological pH (pH 6.8) and acidic pH that mimics phagosomal environment (pH 5.7).2026/05/01GSE296247GSM8967656GSM8967667GSM8967657GSM8967658GSM8967659GSM8967663GSM8967652GSM8967653GSM8967664GSM8967665GSM8967654GSM8967666GSM8967655GSM8967660GSM8967650GSM8967661GSM8967662GSM896765125317296247Mycobacterium tuberculosis