{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE296nnn/GSE296275/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Mus musculus"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296275"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Distinct tissue niches contribute to prostate TRM cell differentiation and heterogeneity [Spatial Transcriptomics]","description":"The prostate is an important exocrine organ, a barrier tissue of the male reproductive system, and a common site of malignancy, yet prostate CD8+ T cells remain largely uncharacterized. Here, we show that a protective, heterogeneous pool of long-lived, tissue-resident memory CD8+ T (Trm) cells forms in the prostate following acute infection in mice. Characterization of prostate Trm cell differentiation over time and functional interrogation of cytokine TGFβ-, IL-7-, and IL-15 signaling revealed niche-dependent phenotypic and functional diversity arising from distinct prostate stromal and glandular epithelial niches in both mice and humans. For instance, the Trm-promoting cytokines IL-15 and TGFβ were highest in the prostate epithelium, where CD8+ T cells were most persistent, cytotoxic, and enriched for the Trm molecular program. In sum, we provide a spatial framework for prostate Trm cell differentiation, charting discrete tissue regions that influence T cell fate through dynamic regulation of localized signals.","dates":{"publication":"2026/03/31"},"accession":"GSE296275","cross_references":{"GSM":["GSM8967906","GSM8967907","GSM8967908","GSM8967909"],"GPL":["33896"],"GSE":["296275"],"taxon":["Mus musculus"]}}