{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE296nnn/GSE296372/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Rattus norvegicus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"," Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296372"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Paternal methamphetamine exposure enhances methamphetamine susceptibility in male rat offspring","description":"We previously demonstrated that male progeny of cocaine-experienced sires resisted cocaine, expressed as delayed acquisition of cocaine self-administration. Here, we sought to determine whether this phenotype extended to another psychostimulant, methamphetamine. Surprisingly, relative to saline-sired rats, male, but not female, methamphetamine-sired offspring demonstrated increased susceptibility to methamphetamine taking. Single nuclei RNA- and ATAC-sequencing of the nucleus accumbens was used to identify molecular drivers of phenotypes in cocaine- and methamphetamine-sired offspring. Sequencing results revealed unique profiles of gene expression and open chromatin in offspring nucleus accumbens. Differential gene expression in cocaine-resistant, cocaine-sired offspring and methamphetamine-susceptible, methamphetamine-sired offspring illuminates potential novel treatment targets for psychostimulant use disorders.","dates":{"publication":"2026/08/12"},"accession":"GSE296372","cross_references":{"GSM":["GSM8969354","GSM8969353","GSM8969356","GSM8969355","GSM8969350","GSM8969352","GSM8969351","GSM8969347","GSM8969358","GSM8969357","GSM8969349","GSM8969348"],"GPL":["25947"],"GSE":["296372"],"taxon":["Rattus norvegicus"]}}