{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE296nnn/GSE296419/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":[" Other","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296419"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"The critical role of the host endogenous immune compartment after intracerebroventricular CAR T cell therapy in recurrent GBM","description":"Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, with a median survival of under 15 months and no effective treatment after recurrence. A recent phase I trial of intracerebroventricular (ICV) bivalent CAR T cells in recurrent GBM showed promising responses, including tumor reduction and prolonged survival. However, relapse remains common. We performed in-depth profiling of longitudinal CSF and tumor samples from responders and non-responders to characterize immune dynamics following infusion. Our study reveals that while CAR T cells activate post-infusion across all patients, outcomes were defined by divergent remodeling of the endogenous immune landscape. Cytotoxic NK cell expansion characterized responders, whereas regulatory T cell expansion and abundant baseline immunosuppressive myeloid cells characterized non-responders. These findings indicate that host immune cells play a critical role in ICV CAR T cell therapy for GBM, suggesting that combinatorial strategies modulating the endogenous immune compartment could improve next-generation treatments.","dates":{"publication":"2026/06/30"},"accession":"GSE296419","cross_references":{"GSM":["GSM9543421","GSM9543420","GSM9543423","GSM9543422","GSM9543425","GSM9543424","GSM9543427","GSM9543426","GSM9543429","GSM9543428","GSM8970101","GSM8970100","GSM9543419","GSM8970109","GSM8970108","GSM8970107","GSM8970106","GSM8970105","GSM8970104","GSM8970103","GSM8970102","GSM9543410","GSM9543412","GSM9543411","GSM9543414","GSM9543413","GSM9543416","GSM9543415","GSM9543418","GSM9543417","GSM9543409","GSM8970112","GSM9543408","GSM8970111","GSM8970110","GSM8970119","GSM8970118","GSM8970117","GSM8970116","GSM8970115","GSM8970114","GSM8970113","GSM9543407","GSM9543406","GSM8970123","GSM8970122","GSM8970121","GSM8970120","GSM8970129","GSM8970128","GSM8970127","GSM8970126","GSM8970125","GSM8970124","GSM9543470","GSM9543472","GSM9543471","GSM9543474","GSM9543473","GSM9543476","GSM9543475","GSM9543478","GSM9543477","GSM8970134","GSM8970133","GSM8970099","GSM8970132","GSM8970131","GSM8970098","GSM8970097","GSM8970130","GSM8970139","GSM8970138","GSM8970137","GSM8970136","GSM8970135","GSM9543461","GSM9543460","GSM9543463","GSM9543462","GSM9543465","GSM9543464","GSM9543467","GSM9543466","GSM9543469","GSM9543468","GSM8970145","GSM8970144","GSM8970143","GSM8970142","GSM8970141","GSM8970140","GSM8970149","GSM8970148","GSM8970147","GSM8970146","GSM9543450","GSM9543452","GSM9543451","GSM9543454","GSM9543453","GSM9543456","GSM9543455","GSM9543458","GSM9543457","GSM9543459","GSM8970156","GSM8970155","GSM8970154","GSM8970153","GSM8970152","GSM8970151","GSM8970150","GSM8970159","GSM8970158","GSM8970157","GSM9543441","GSM9543440","GSM9543443","GSM9543442","GSM9543445","GSM9543444","GSM9543447","GSM9543446","GSM9543449","GSM9543448","GSM8970166","GSM8970165","GSM8970164","GSM8970163","GSM8970162","GSM8970161","GSM8970160","GSM9543430","GSM9543432","GSM9543431","GSM9543434","GSM9543433","GSM9543436","GSM9543435","GSM9543438","GSM9543437","GSM9543439"],"GPL":["18573","24676","34281"],"GSE":["296419"],"taxon":["Homo sapiens"]}}