{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE296nnn/GSE296587/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"," Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296587"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Sequencing DNA methylation and hydroxymethylation at co-occurring chromatin features","description":"Epigenetic modifications govern chromatin dynamics and cell state. However, current methods cannot simultaneously resolve the presence of multiple DNA modifications at co-occurring chromatin-associated features. It is thus not clear how these features are physically coupled and how their combinations regulate genome function. To address this key question, we report 6-base-CUT&Tag, a method for simultaneous 6-base sequencing at target chromatin features. Using 6-base-CUT&Tag to profile 5mC and 5hmC at co-occurring histone modifications in mouse embryonic stem cells, we identify histone mark-specific signatures of methylation and hydroxymethylation to improve discrimination of different functional enhancer states.","dates":{"publication":"2026/01/15"},"accession":"GSE296587","cross_references":{"GSM":["GSM9349170","GSM9349171","GSM9349174","GSM9349175","GSM9349172","GSM9349173","GSM8972984","GSM8972985","GSM8972986","GSM8972987","GSM8972988","GSM9349178","GSM9349179","GSM9349176","GSM9349177","GSM8972980","GSM8972981","GSM8972982","GSM8972983","GSM9349163","GSM9349164","GSM9349161","GSM9349162","GSM8972977","GSM8972978","GSM8972979","GSM9349167","GSM9349168","GSM9349165","GSM9349166","GSM9349169"],"GPL":["30172","24247"],"GSE":["296587"],"taxon":["Mus musculus"],"PMID":["[41667493]"]}}