GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE296nnn/GSE296604/primaryOK200GenomicsMus musculusNon-coding RNA profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296604GEOGSEfalseFentanyl-Induced Rapid Cortical Damage and Cardiopulmonary Arrest Linked to Atypical Dynamics of Apoptosis and Immune Response in a Mouse Model [miRNA]The rapid onset of fentanyl impairs cardiopulmonary and neurological function, often outpacing clinical intervention. To understand its tissue-specific molecular effects, we administered three escalating doses of fentanyl (HNLD, LD10, and LD50) to SKH-1 mice and collected cortex, heart, and lung samples at 0h, 6h, 24h, and 7d post-injection. This study employed miRNA-seq to uncover conserved regulatory signatures underlying apoptosis and immune response networks. Using a machine-learning pipeline, we identified phylogenetically conserved miRNA-mRNA axes with translational potential, such as miR-877-3p in cortex and miR-146b-5p in lungs, providing early leads for therapeutic intervention in fentanyl overdose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 musculus[41948326]