GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE296nnn/GSE296772/primaryOK200TranscriptomicsMus musculusExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296772GEOGSEfalseAssessment of the Health Effects of Phytopharmaceuticals Used in Potato Cultivation [Brain]Potatoes are one of the most widely consumed staple foods globally, yet their cultivation and storage often involve the use of multiple phytopharmaceutical products, raising concerns about potential health impacts from dietary pesticide residues. The health effects of multi-residue phytopharmaceutical products used in potato cultivation were assessed using an in vivo murine model and evaluated through omics analyses. Two cultivation methods (conventional and organic) and two storage conditions (using 1,4-dimethylnaphthalene and essential mint oil as sprout inhibitor treatments) were considered. Potato tubers from the different conditions were processed into flour and administered to the animals at a moderate daily dose for 20 consecutive days. Nutrigenomic analyses were performed to reveal the impact of differently treated potatoes on gene expression in liver, jejunum and brain. Additionally, metagenomic analyses were conducted to observe changes in the intestinal microbiota. Ingestion of phytopharmaceutical products contained in food showed significant effects on gene expression and on the intestinal microbiota. The observed gene deregulations suggest disturbances in cellular proliferation, nervous system development and activity, lipid and carbohydrate metabolism, reproductive health, and immune responses. Microbiota imbalances were observed, notably a shift in the Firmicutes/Bacteroidota ratio. The main residues suspected of producing these effects include propamocarb, carfentrazone, 1,4-dimethylnaphthalene, copper derivatives, and peppermint essential oil. Taken together, these findings highlight the importance of large-scale omics approaches in uncovering potential biological disruptions, underscore the health risks associated with chronic dietary exposure to pesticide residues—particularly in mixtures—and emphasize the need to reassess regulatory standards and promote agricultural practices that minimize pesticide residues to better protect public health.2026/05/25GSE296772GSM8976330GSM8976319GSM8976328GSM8976317GSM8976318GSM8976329GSM8976322GSM8976323GSM8976331GSM8976320GSM8976321GSM8976315GSM8976326GSM8976327GSM8976316GSM8976324GSM8976325GSM897631410333296772Mus musculus