GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE296nnn/GSE296887/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296887GEOGSEfalseA Novel Therapeutic Agent: Harnessing Macrophage Polarization to Combat Sepsis and Alleviate Lung InjurySepsis is a complex syndrome characterized by dysregulated immune responses, with macrophage polarization being pivotal in its immunomodulation. Lung injury is a prevalent and severe consequence in sepsis. This research delved into the therapeutic potential of JSNPs. Initially, investigations involving bioinformatics analysis and JHU083 treatment revealed that while JHU083 extended septic mice's survival, it had limited impact on lung injury.Subsequently, studies on JSNPs showed it could improve sepsis and lung injury in CLP and LPS models. Mechanistically, JSNPs promoted macrophage polarization towards the anti - inflammatory M2 phenotype, safeguarding neurons from sepsis - induced lung injury. Further experiments demonstrated that JSNPs's protection of lung neurons was M2 macrophage dependent, and macrophages released neurotrophic factors under JSNPs's influence to shield neurons. Overall, JSNPs emerges as a promising candidate for treating sepsis and its associated lung injury.2026/05/12GSE296887GSM8979432GSM8979431GSM8979430GSM8979429GSM8979428GSM897942724247296887Mus musculus[41698047]