{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE296nnn/GSE296902/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296902"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Target macrophage SPP1 promtes CD8 T cell infiltrations","description":"SPP1 in tumor associated macrophages (TAM) can inhibit the infiltration of CD8 T cells, promote tumor growth, and reduce the efficacy of ICI immunotherapy. Single cell (sc)-RNA sequencing data showed markedly increased CD8 T cells in the tumor tissues of SPP1fl/fl-Lyz2-icre mice compared to control SPP1fl/fl mice.","dates":{"publication":"2026/06/30"},"accession":"GSE296902","cross_references":{"GSM":["GSM8979630","GSM8979631"],"GPL":["24247"],"GSE":["296902"],"taxon":["Mus musculus"]}}