GEOTranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297057GEOGSEfalseMulti-omics analysis in EGFR-mutant lung adenocarcinomaUsing genomic and transcriptomic anaysis, we have identified TP53-GOF mutations as key genomic alterations associated with early resistance to first-line osimertinib therapy in EGFR-mutant NSCLC. Through comprehensive genomic and transcriptomic profiling, we found that TP53-GOF mutations define a biologically distinct subgroup marked by significantly shorter progression-free survival against osimrtinib treatment.2026/05/11GSE297057GSM8982761GSM8982762GSM8982760GSM8982747GSM8982748GSM8982745GSM8982746GSM8982765GSM8982743GSM8982766GSM8982744GSM8982763GSM8982741GSM8982742GSM8982764GSM8982750GSM8982751GSM8982758GSM8982759GSM8982756GSM8982757GSM8982754GSM8982755GSM8982752GSM8982753GSM898274934284297057Homo sapiens