{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297068/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["synthetic construct"," Mus musculus"],"gds_type":[" Other","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297068"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain","description":"Although topographical maps organize many peripheral sensory systems, mouse olfactory sensory neurons (OSNs) are thought to randomly choose which one of ~1,100 possible olfactory receptors (ORs) to express, with spatial organization in the olfactory epithelium limited to a handful of broad anatomical zones that modestly restrict OR choice. Here we reveal that each OR is instead expressed at a unique mean dorsoventral position, thereby instantiating a stereotyped receptor map in the olfactory epithelium. OSN dorsoventral identities are encoded by a coherent gene expression program, which includes key transcription factors and axon guidance molecules; use of this program reflects a dorsoventral gradient in retinoic acid signaling, translates each physical location into a spatially appropriate distribution of potential OR choices, and aligns receptor maps in the nose and brain. Spatial order in the olfactory system, therefore, arises from a continuously varying transcriptional code that precisely organizes the many discrete channels responsible for smell.","dates":{"publication":"2026/04/21"},"accession":"GSE297068","cross_references":{"GSM":["GSM8983099","GSM8983098","GSM8983097","GSM8983096","GSM8983095","GSM8983094","GSM8983093","GSM8983092","GSM8983091","GSM8983090","GSM8983301","GSM8983300","GSM8983309","GSM8983308","GSM8983307","GSM8983306","GSM8983305","GSM8983304","GSM8983303","GSM8983302","GSM8983312","GSM8983311","GSM8983310","GSM8983319","GSM8983318","GSM8983317","GSM8983316","GSM8983315","GSM8983314","GSM8983313","GSM8983202","GSM8983323","GSM8983322","GSM8983201","GSM8983200","GSM8983321","GSM8983320","GSM8983209","GSM8983208","GSM8983329","GSM8983328","GSM8983207","GSM8983206","GSM8983327","GSM8983205","GSM8983326","GSM8983325","GSM8983204","GSM8983203","GSM8983324","GSM8983213","GSM8983334","GSM8983333","GSM9577757","GSM8983212","GSM8983211","GSM8983332","GSM8983210","GSM8983331","GSM9577754","GSM8983330","GSM9577756","GSM9577755","GSM8983219","GSM8983339","GSM8983218","GSM8983217","GSM8983338","GSM8983216","GSM8983337","GSM8983336","GSM8983215","GSM8983214","GSM8983335","GSM8983345","GSM8983103","GSM8983224","GSM8983102","GSM8983223","GSM8983344","GSM8983222","GSM8983343","GSM8983101","GSM8983342","GSM8983100","GSM8983221","GSM8983220","GSM8983341","GSM8983340","GSM8983109","GSM8983108","GSM8983229","GSM8983107","GSM8983228","GSM8983348","GSM8983106","GSM8983227","GSM8983105","GSM8983226","GSM8983347","GSM8983104","GSM8983225","GSM8983346","GSM8983114","GSM8983235","GSM8983113","GSM8983234","GSM8983233","GSM8983112","GSM8983111","GSM8983232","GSM8983110","GSM8983231","GSM8983230","GSM9579157","GSM8983119","GSM9579158","GSM8983239","GSM8983118","GSM8983117","GSM8983238","GSM8983116","GSM8983237","GSM8983236","GSM8983115","GSM8983125","GSM8983246","GSM8983245","GSM8983124","GSM8983123","GSM8983244","GSM8983122","GSM8983243","GSM8983242","GSM8983121","GSM8983120","GSM8983241","GSM8983240","GSM8983129","GSM8983128","GSM8983249","GSM8983127","GSM8983248","GSM8983126","GSM8983247","GSM8983136","GSM8983257","GSM8983256","GSM8983135","GSM8983134","GSM8983255","GSM8983133","GSM8983254","GSM8983253","GSM8983132","GSM8983131","GSM8983252","GSM8983130","GSM8983251","GSM8983250","GSM8983139","GSM8983259","GSM8983138","GSM8983137","GSM8983258","GSM8983147","GSM8983268","GSM8983146","GSM8983267","GSM8983145","GSM8983266","GSM8983265","GSM8983144","GSM8983143","GSM8983264","GSM8983142","GSM8983263","GSM8983262","GSM8983141","GSM8983140","GSM8983261","GSM8983149","GSM8983148","GSM8983269","GSM8983260","GSM8983279","GSM8983158","GSM8983157","GSM8983278","GSM9578549","GSM8983156","GSM8983277","GSM8983276","GSM8983155","GSM8983154","GSM9578547","GSM8983275","GSM8983153","GSM8983274","GSM9578548","GSM8983273","GSM8983152","GSM9578546","GSM8983151","GSM8983272","GSM8983159","GSM8983150","GSM8983271","GSM8983270","GSM8983169","GSM8983168","GSM8983289","GSM8983167","GSM8983288","GSM8983166","GSM8983287","GSM8983165","GSM8983286","GSM8983285","GSM8983164","GSM8983163","GSM8983284","GSM8983162","GSM8983283","GSM8983282","GSM8983161","GSM8983160","GSM8983281","GSM8983280","GSM8983179","GSM8983299","GSM8983178","GSM8983177","GSM8983298","GSM8983176","GSM8983297","GSM8983296","GSM8983175","GSM8983174","GSM8983295","GSM8983173","GSM8983294","GSM8983293","GSM8983172","GSM8983171","GSM8983292","GSM8983170","GSM8983291","GSM8983290","GSM8983069","GSM8983068","GSM8983189","GSM8983188","GSM8983187","GSM8983186","GSM8983185","GSM8983184","GSM8983183","GSM8983182","GSM8983181","GSM8983180","GSM8983079","GSM8983199","GSM8983078","GSM8983077","GSM8983198","GSM8983076","GSM8983197","GSM8983196","GSM8983075","GSM8983074","GSM8983195","GSM8983073","GSM8983194","GSM8983193","GSM8983072","GSM8983071","GSM8983192","GSM8983070","GSM8983191","GSM8983190","GSM8983089","GSM8983088","GSM8983087","GSM8983086","GSM8983085","GSM8983084","GSM8983083","GSM8983082","GSM8983081","GSM8983080"],"GPL":["28330","24247","31217","34290"],"GSE":["297068"],"taxon":["synthetic construct"," Mus musculus"]}}