{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297153/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297153"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Target macrophage SPP1 promotes CD8 T cell infiltrations","description":"SPP1 in tumor associated macrophages (TAM) can inhibit the infiltration of CD8 T cells, promote tumor growth, and reduce the efficacy of ICI immunotherapy. RNA sequencing data showed diffrential expressed genes and enrichment pathway in the bone marrow derived macrophages from SPP1fl/fl-Lyz2-icre mice compared to control SPP1fl/fl mice.","dates":{"publication":"2026/06/30"},"accession":"GSE297153","cross_references":{"GSM":["GSM8984731","GSM8984730"],"GPL":["30215"],"GSE":["297153"],"taxon":["Mus musculus"]}}