{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297196/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Methylation profiling"],"species":["Mus musculus"],"gds_type":["Methylation profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297196"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"m6A RIP-seq of beta-cell s from liver-specific insulin receptor knockout (LIRKO) mice","description":"In type 2 diabetes, pancreatic beta-cells fail to compensate for the presence of insulin resistance in target tissues. Identifying and studying innovative molecular mechanisms that control the beta-cell adaptation to insulin resistance represent an interesting line of research and are necessary. N6-Methyladenosine (m6A) is the most abundant modification in mRNA and is found virtually in all mammals. Through m6A-profiling of Control and LIRKO islets we aimed to identify the m6A landscape of the successful beta-cell adaption to insulin resistance.","dates":{"publication":"2026/05/14"},"accession":"GSE297196","cross_references":{"GSM":["GSM8985458","GSM8985436","GSM8985437","GSM8985459","GSM8985438","GSM8985450","GSM8985451","GSM8985452","GSM8985430","GSM8985431","GSM8985453","GSM8985454","GSM8985432","GSM8985455","GSM8985433","GSM8985434","GSM8985456","GSM8985457","GSM8985435","GSM8985447","GSM8985448","GSM8985449","GSM8985427","GSM8985428","GSM8985429","GSM8985461","GSM8985462","GSM8985460"],"GPL":["21103"],"GSE":["297196"],"taxon":["Mus musculus"]}}