{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297328/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297328"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Longitudinal single-cell RNA sequencing of a neuroendocrine transdifferentiation model reveals transcriptional reprogramming in treatment-induced neuroendocrine prostate cancer","description":"To investigate the dynamic changes of prostate cancer cells during neuroendocrine transdifferentiation (NEtD), we performed single-cell RNA sequencing (scRNA-seq) on longtitudinal LTL331 PDX model derived from patient samples. Analysis of the data depicts a comprehensive cellular and molecular landscape during NEtD, which would be a valuable resource for the development of strategies to delay or prevent NEtD with the potential of identifying novel prognostic and therapeutic targets","dates":{"publication":"2026/09/30"},"accession":"GSE297328","cross_references":{"GSM":["GSM8988649","GSM8988648","GSM8988650","GSM8988643","GSM8988645","GSM8988644","GSM8988647","GSM8988646"],"GPL":["21697","28337"],"GSE":["297328"],"taxon":["Homo sapiens"]}}