GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297328/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297328GEOGSEfalseLongitudinal single-cell RNA sequencing of a neuroendocrine transdifferentiation model reveals transcriptional reprogramming in treatment-induced neuroendocrine prostate cancerTo investigate the dynamic changes of prostate cancer cells during neuroendocrine transdifferentiation (NEtD), we performed single-cell RNA sequencing (scRNA-seq) on longtitudinal LTL331 PDX model derived from patient samples. Analysis of the data depicts a comprehensive cellular and molecular landscape during NEtD, which would be a valuable resource for the development of strategies to delay or prevent NEtD with the potential of identifying novel prognostic and therapeutic targets2026/09/30GSE297328GSM8988649GSM8988648GSM8988650GSM8988643GSM8988645GSM8988644GSM8988647GSM89886462169728337297328Homo sapiens