{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297388/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Mus musculus"],"gds_type":[" Expression profiling by high throughput sequencing","Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297388"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Spatial transcriptomics and scRNA-sequencing on gastrocnemius muscle form B6-mdx and D2-mdx mice","description":"We investigated the cell-type composition of muscle domains that associate with muscle degeneration severity in two mouse models of human DMD, namely the B6.mdx and D2.mdx. We first combined immunofluorescence-based histological analysis and spatial transcriptomics to highlight specific muscle tissue clusters that display dystrophic features with necrotic fibers, inflammatory cell infiltration and increased fibrosis. Using single-cell RNA-sequencing reference and spatial deconvolution, we profiled cell types and states within each dystrophic domain, thereby identifying the enrichment for specific cell subpopulations in these spatial clusters.","dates":{"publication":"2026/07/01"},"accession":"GSE297388","cross_references":{"GSM":["GSM8989880","GSM8989882","GSM8989881","GSM8989875","GSM8989877","GSM8989876","GSM8989879","GSM8989878"],"GPL":["17021"],"GSE":["297388"],"taxon":["Mus musculus"],"PMID":["[42067923]"]}}