GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297388/primaryOK200OtherMus musculus Expression profiling by high throughput sequencingOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297388GEOGSEfalseSpatial transcriptomics and scRNA-sequencing on gastrocnemius muscle form B6-mdx and D2-mdx miceWe investigated the cell-type composition of muscle domains that associate with muscle degeneration severity in two mouse models of human DMD, namely the B6.mdx and D2.mdx. We first combined immunofluorescence-based histological analysis and spatial transcriptomics to highlight specific muscle tissue clusters that display dystrophic features with necrotic fibers, inflammatory cell infiltration and increased fibrosis. Using single-cell RNA-sequencing reference and spatial deconvolution, we profiled cell types and states within each dystrophic domain, thereby identifying the enrichment for specific cell subpopulations in these spatial clusters.2026/07/01GSE297388GSM8989880GSM8989882GSM8989881GSM8989875GSM8989877GSM8989876GSM8989879GSM898987817021297388Mus musculus[42067923]