{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297397"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Leukemia risk factor ARID5B Coordinates HDAC-Mediated Transcriptional Repression [RNA-Seq]","description":"We employed a combination of proteomics, genomics and transcriptomics to describe the molecular mechanisms of ARID5B. We identify that ARID5B interacts with MIER1, C16ORF87, HDAC1 and HDAC2 forming a repressor complex. The former localizes to active regions of the genome, tethering HDAC1 and HDAC2 to enhancers and promoters. Genes actively repressed by the ARID5B repressor complex are involved in B cell-specific signaling.","dates":{"publication":"2026/05/19"},"accession":"GSE297397","cross_references":{"GSM":["GSM8990109","GSM8990108","GSM8990099","GSM8990110","GSM8990103","GSM8990102","GSM8990101","GSM8990100","GSM8990107","GSM8990106","GSM8990105","GSM8990104"],"GPL":["24676"],"GSE":["297397"],"taxon":["Homo sapiens"]}}