GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297397/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297397GEOGSEfalseLeukemia risk factor ARID5B Coordinates HDAC-Mediated Transcriptional Repression [RNA-Seq]We employed a combination of proteomics, genomics and transcriptomics to describe the molecular mechanisms of ARID5B. We identify that ARID5B interacts with MIER1, C16ORF87, HDAC1 and HDAC2 forming a repressor complex. The former localizes to active regions of the genome, tethering HDAC1 and HDAC2 to enhancers and promoters. Genes actively repressed by the ARID5B repressor complex are involved in B cell-specific signaling.2026/05/19GSE297397GSM8990109GSM8990108GSM8990099GSM8990110GSM8990103GSM8990102GSM8990101GSM8990100GSM8990107GSM8990106GSM8990105GSM899010424676297397Homo sapiens