{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297398/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297398"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Leukemia risk factor ARID5B Coordinates HDAC-Mediated Transcriptional Repression [CUT&Run]","description":"We employed a combination of proteomics, genomics and transcriptomics to describe the molecular mechanisms of ARID5B. We identify that ARID5B interacts with MIER1, C16ORF87, HDAC1 and HDAC2 forming a repressor complex. The former localizes to active regions of the genome, tethering HDAC1 and HDAC2 to enhancers and promoters. Genes actively repressed by the ARID5B repressor complex are involved in B cell-specific signaling.","dates":{"publication":"2026/05/19"},"accession":"GSE297398","cross_references":{"GSM":["GSM8990150","GSM8990132","GSM8990154","GSM8990153","GSM8990131","GSM8990152","GSM8990130","GSM8990151","GSM8990136","GSM8990114","GSM8990135","GSM8990113","GSM8990157","GSM8990112","GSM8990156","GSM8990134","GSM8990155","GSM8990133","GSM8990111","GSM8990118","GSM8990117","GSM8990139","GSM8990138","GSM8990116","GSM8990137","GSM8990115","GSM8990119","GSM8990143","GSM8990121","GSM8990120","GSM8990142","GSM8990141","GSM8990140","GSM8990147","GSM8990125","GSM8990146","GSM8990124","GSM8990123","GSM8990145","GSM8990144","GSM8990122","GSM8990129","GSM8990128","GSM8990149","GSM8990127","GSM8990126","GSM8990148"],"GPL":["24676"],"GSE":["297398"],"taxon":["Homo sapiens"]}}