GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297398/primaryOK200GenomicsHomo sapiensGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297398GEOGSEfalseLeukemia risk factor ARID5B Coordinates HDAC-Mediated Transcriptional Repression [CUT&Run]We employed a combination of proteomics, genomics and transcriptomics to describe the molecular mechanisms of ARID5B. We identify that ARID5B interacts with MIER1, C16ORF87, HDAC1 and HDAC2 forming a repressor complex. The former localizes to active regions of the genome, tethering HDAC1 and HDAC2 to enhancers and promoters. Genes actively repressed by the ARID5B repressor complex are involved in B cell-specific signaling.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 sapiens