{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297670/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297670"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Splice-altering TP53 missense mutations: Drivers of functional loss and therapeutic targets via RNA modulation","description":"Using bacterial artificial chromosome DNA-mediated targeting, we developed knock-in TP53 mutant cell models including c.182A>G, c.318C>G, c.356C>G and c.362C>A. These missense mutations can function as frameshift or hypomorphic mutations due to aberrant splicing, significantly compromising TP53 mRNA integrity.","dates":{"publication":"2026/05/31"},"accession":"GSE297670","cross_references":{"GSM":["GSM8996382","GSM8996393","GSM8996394","GSM8996383","GSM8996391","GSM8996380","GSM8996381","GSM8996392","GSM8996390","GSM8996379","GSM8996388","GSM8996377","GSM8996378","GSM8996389","GSM8996386","GSM8996387","GSM8996384","GSM8996385"],"GPL":["28038"],"GSE":["297670"],"taxon":["Homo sapiens"]}}