GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297670/primary200OKTranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297670GEOGSEfalseSplice-altering TP53 missense mutations: Drivers of functional loss and therapeutic targets via RNA modulationUsing bacterial artificial chromosome DNA-mediated targeting, we developed knock-in TP53 mutant cell models including c.182A>G, c.318C>G, c.356C>G and c.362C>A. These missense mutations can function as frameshift or hypomorphic mutations due to aberrant splicing, significantly compromising TP53 mRNA integrity.2026/05/31GSE297670GSM8996382GSM8996393GSM8996394GSM8996383GSM8996391GSM8996380GSM8996381GSM8996392GSM8996390GSM8996379GSM8996388GSM8996377GSM8996378GSM8996389GSM8996386GSM8996387GSM8996384GSM899638528038297670Homo sapiens