{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297681/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297681"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Pregnane X Receptor-Mediated Liver Growth: A Controlled Clinical Study In Humans And Identification Of The Role Of Akt-Mtor-Pathway In Mouse","description":"Pregnane X receptor (PXR) is a nuclear receptor acting as a master xenobiotic receptor for many exogenous chemicals. Activation of PXR has been linked to liver growth in mice. Pxr-/- mice were transduced with adenovirus carrying either murine PXR or green fluorescent protein(GFP) as a control and both groups were treated with pregnenolone-16α-carbonitrile (PCN) for 1 to 4 days. In this setup, activation of PXR with PCN significantly increased liver size in male mice and this growth was associated with the activation of proliferative AKT-mTOR pathway.","dates":{"publication":"2026/09/03"},"accession":"GSE297681","cross_references":{"GSM":["GSM8996621","GSM8996622","GSM8996620","GSM8996627","GSM8996625","GSM8996626","GSM8996623","GSM8996624"],"GPL":["24247"],"GSE":["297681"],"taxon":["Mus musculus"]}}