GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297681/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297681GEOGSEfalsePregnane X Receptor-Mediated Liver Growth: A Controlled Clinical Study In Humans And Identification Of The Role Of Akt-Mtor-Pathway In MousePregnane X receptor (PXR) is a nuclear receptor acting as a master xenobiotic receptor for many exogenous chemicals. Activation of PXR has been linked to liver growth in mice. Pxr-/- mice were transduced with adenovirus carrying either murine PXR or green fluorescent protein(GFP) as a control and both groups were treated with pregnenolone-16α-carbonitrile (PCN) for 1 to 4 days. In this setup, activation of PXR with PCN significantly increased liver size in male mice and this growth was associated with the activation of proliferative AKT-mTOR pathway.2026/09/03GSE297681GSM8996621GSM8996622GSM8996620GSM8996627GSM8996625GSM8996626GSM8996623GSM899662424247297681Mus musculus