{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297728/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297728"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Synergistic activity of simvastatin and irinotecan chemotherapy against glioblastoma converges on TGF-β","description":"Glioblastoma (GBM) is the most common and aggressive primary brain tumor, with a dismal prognosis and inevitable recurrence after standard-of-care therapy. This warrants the need for rapidly translatable, more effective GBM treatments. We have therefore investigated the therapeutic potential of a novel combination of the repurposed drug simvastatin with irinotecan chemotherapy (CPT-11).","dates":{"publication":"2026/05/20"},"accession":"GSE297728","cross_references":{"GSM":["GSM8997623","GSM8997622","GSM8997621","GSM8997620","GSM8997619","GSM8997618","GSM8997617","GSM8997628","GSM8997627","GSM8997616","GSM8997626","GSM8997615","GSM8997614","GSM8997625","GSM8997624","GSM8997613"],"GPL":["30173"],"GSE":["297728"],"taxon":["Homo sapiens"]}}