GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297728/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297728GEOGSEfalseSynergistic activity of simvastatin and irinotecan chemotherapy against glioblastoma converges on TGF-βGlioblastoma (GBM) is the most common and aggressive primary brain tumor, with a dismal prognosis and inevitable recurrence after standard-of-care therapy. This warrants the need for rapidly translatable, more effective GBM treatments. We have therefore investigated the therapeutic potential of a novel combination of the repurposed drug simvastatin with irinotecan chemotherapy (CPT-11).2026/05/20GSE297728GSM8997623GSM8997622GSM8997621GSM8997620GSM8997619GSM8997618GSM8997617GSM8997628GSM8997627GSM8997616GSM8997626GSM8997615GSM8997614GSM8997625GSM8997613GSM899762430173297728Homo sapiens