{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297810/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297810"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Differentially expressed genes in HTR-8/SVneo cell overexpressing miR-26a-5p modulate invasion and migration","description":"Aberrant expression of microRNAs (miRNAs) is a critical factor in the pathogenesis of preeclampsia (PE). miR-26a-5p is a key regulatory miRNA that plays an important role in trophoblast cell function, which is essential during placental development. This study aims to investigate the impact of miR-26a-5p overexpression on the transcriptome of trophoblastic HTR-8/SVneo cells, a commonly used model for studying trophoblast functions in placentas collected from pregnancies complicated by PE. In this study, HTR-8/SVneo cells were transfected with 75 nM miR-26a-5p mimics, and RNA sequencing (RNA-seq) was employed to analyze alterations in gene expression.","dates":{"publication":"2026/05/18"},"accession":"GSE297810","cross_references":{"GSM":["GSM9000101","GSM9000100","GSM9000099","GSM9000098","GSM9000097","GSM9000096"],"GPL":["28038"],"GSE":["297810"],"taxon":["Homo sapiens"]}}