{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297902/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297902"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"TBK1 enhances antifungal immunity by forming a SRC-TBK1 positive feedback loop in phagosomes of macrophages","description":"TBK1 is a serine/threonine kinase known for its role in antiviral immunity. Here, we identify TBK1 as a key amplifier of antifungal immune responses. Using a mouse model of Candida albicans infection, we show that TBK1 is recruited to phagosomes via SRC-SHP2 signaling and phosphorylates SRC to establish a positive feedback loop. This enhances downstream cytokine production, including IL-6 and TNF-α, and promotes fungal clearance. Bone marrow-derived macrophages (BMDMs) from TBK1fl/fl and TBK1fl/fl Lyz2-Cre mice were stimulated with various fungal components, and RNA-seq was performed to assess transcriptional changes. Our findings define a new role for TBK1 in antifungal host defense and suggest TBK1 as a potential therapeutic target.","dates":{"publication":"2025/06/14"},"accession":"GSE297902","cross_references":{"GSM":["GSM9001690","GSM9001680","GSM9001681","GSM9001670","GSM9001671","GSM9001682","GSM9001683","GSM9001672","GSM9001684","GSM9001673","GSM9001685","GSM9001674","GSM9001675","GSM9001686","GSM9001687","GSM9001676","GSM9001688","GSM9001677","GSM9001678","GSM9001689","GSM9001679","GSM9001669"],"GPL":["32159"],"GSE":["297902"],"taxon":["Mus musculus"],"PMID":["[40638388]"]}}