{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298032/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298032"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Host-Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules","description":"The increasing prevalence of emerging infectious diseases highlights the urgent need for broad-spectrum antiviral therapeutics. Here, we report the discovery of SB2960, a small molecule that promotes stress granule (SG) formation and exhibits potent antiviral activity across diverse viral species. Here, we applied genetically-encoded photosentisizer miniSOG induced RNA labeling technique CAP-seq to profile RNA components in SG induced by poly(I:C) and drug SB2960 to investigate how SB2960 modulates the RNAs composition of SGs.","dates":{"publication":"2026/04/28"},"accession":"GSE298032","cross_references":{"GSM":["GSM9005460","GSM9005462","GSM9005451","GSM9005461","GSM9005450","GSM9005453","GSM9005442","GSM9005463","GSM9005452","GSM9005455","GSM9005444","GSM9005443","GSM9005454","GSM9005457","GSM9005446","GSM9005456","GSM9005445","GSM9005459","GSM9005448","GSM9005458","GSM9005447","GSM9005449"],"GPL":["24676"],"GSE":["298032"],"taxon":["Homo sapiens"]}}