{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298143/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298143"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Deficiency of SATB1 in naive CD4+ T cells alters the 3D chromatin structure and promotes T cell aging [CUT&Tag 2]","description":"T cell aging significantly increases the incidence of infections, tumors, and autoimmune diseases in elderly individuals. However, the regulatory factors and molecular mechanisms that influence T cell aging remain unclear. We have previously discovered that the nuclear matrix-binding protein SATB1, a regulatory protein essential for the three-dimensional (3D) genome organization of T cells, plays a pivotal role in T cell activation and the expression of inflammatory genes. Our preliminary results further indicate that during T cell aging, SATB1 expression markedly decreases, resulting in alterations in the 3D genome organization through modulation of CTCF-mediated chromatin interactions. These structural changes subsequently affect the gene expression profile of T cells, thereby promoting the progression of T cell aging. This study aims to further elucidate the molecular mechanisms by which the downregulation of SATB1 remodels the 3D genome organization of T cells, and investigate the protective effects of restoring SATB1 expression on T cell aging. These findings will provide new insights into the mechanisms of T cell aging and may unveil potential therapeutic target for the clinical management of age-related immune decline.","dates":{"publication":"2026/08/24"},"accession":"GSE298143","cross_references":{"GSM":["GSM9009048","GSM9009047","GSM9009046","GSM9009045","GSM9009049","GSM9009051","GSM9009050","GSM9009044","GSM9009043","GSM9009052"],"GPL":["24247"],"GSE":["298143"],"taxon":["Mus musculus"]}}