{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298153/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":[" Genome binding/occupancy profiling by high throughput sequencing","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298153"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"SOX4 Mediated Differentiation of Specific T Lymphocyte Subsets at the Maternal-Fetal Interface Contributes to Preterm Labor","description":"The initiation of labor and preterm labor is a complex and precise physiological process involving a well-orchestrated dialogue between the mother and fetus. Immunological tolerance toward the semiallogeneic fetus is one of many maternal adaptations required for a successful pregnancy. T lymphocyte are major players of the adaptive immune system and balance tolerance and protection at the maternal-fetal interface. However, the dynamics, repertoire and subset programming of T cells across labor are still poorly understood. Here we integrated single-cell RNA sequencing and single-cell ATAC sequencing analyses of human decidua basalis and decidua parietalis from term and preterm labor to depict the composition of T cells at the maternal-fetal interface during late pregnancy and to investigate the potential mechanisms underlying the occurrence of preterm labor.","dates":{"publication":"2026/05/13"},"accession":"GSE298153","cross_references":{"GSM":["GSM9009169","GSM9009168","GSM9009167","GSM9009166","GSM9009161","GSM9009172","GSM9009171","GSM9009170","GSM9009176","GSM9009165","GSM9009164","GSM9009175","GSM9009174","GSM9009163","GSM9009173","GSM9009162"],"GPL":["24676"],"GSE":["298153"],"taxon":["Homo sapiens"]}}