GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298153/primaryOK200TranscriptomicsHomo sapiens Genome binding/occupancy profiling by high throughput sequencingExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298153GEOGSEfalseSOX4 Mediated Differentiation of Specific T Lymphocyte Subsets at the Maternal-Fetal Interface Contributes to Preterm LaborThe initiation of labor and preterm labor is a complex and precise physiological process involving a well-orchestrated dialogue between the mother and fetus. Immunological tolerance toward the semiallogeneic fetus is one of many maternal adaptations required for a successful pregnancy. T lymphocyte are major players of the adaptive immune system and balance tolerance and protection at the maternal-fetal interface. However, the dynamics, repertoire and subset programming of T cells across labor are still poorly understood. Here we integrated single-cell RNA sequencing and single-cell ATAC sequencing analyses of human decidua basalis and decidua parietalis from term and preterm labor to depict the composition of T cells at the maternal-fetal interface during late pregnancy and to investigate the potential mechanisms underlying the occurrence of preterm labor.2026/05/13GSE298153GSM9009169GSM9009168GSM9009167GSM9009166GSM9009161GSM9009172GSM9009171GSM9009170GSM9009176GSM9009165GSM9009164GSM9009175GSM9009174GSM9009163GSM9009173GSM900916224676298153Homo sapiens