{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298180/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298180"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"METTL3-dependent m6A methylation in atherogenic endothelial inflammation [RNA]","description":"Atherosclerosis is initiated by endothelial inflammation. Using RNA-seq and eCLIP, we identified METTL3 as a mechanosensitive m6A writer that upregulates NLRP1 and downregulates KLF4 through YTHDF readers. Knockdown of METTL3 abrogated these changes and protected against flow-induced atherogenesis in vitro and in vivo.","dates":{"publication":"2026/06/26"},"accession":"GSE298180","cross_references":{"GSM":["GSM9009587","GSM9009586","GSM9009585","GSM9009584","GSM9009589","GSM9009588","GSM9009583","GSM9009582","GSM9009581"],"GPL":["16791"],"GSE":["298180"],"taxon":["Homo sapiens"]}}