GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298180/primary200OKTranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298180GEOGSEfalseMETTL3-dependent m6A methylation in atherogenic endothelial inflammation [RNA]Atherosclerosis is initiated by endothelial inflammation. Using RNA-seq and eCLIP, we identified METTL3 as a mechanosensitive m6A writer that upregulates NLRP1 and downregulates KLF4 through YTHDF readers. Knockdown of METTL3 abrogated these changes and protected against flow-induced atherogenesis in vitro and in vivo.2026/06/26GSE298180GSM9009587GSM9009586GSM9009585GSM9009584GSM9009589GSM9009588GSM9009583GSM9009582GSM900958116791298180Homo sapiens