{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298183/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298183"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"METTL3-dependent m6A methylation in atherogenic endothelial inflammation [eCLIP]","description":"Atherosclerosis is initiated by endothelial inflammation. Using RNA-seq and eCLIP, we identified METTL3 as a mechanosensitive m6A writer that upregulates NLRP1 and downregulates KLF4 through YTHDF readers. Knockdown of METTL3 abrogated these changes and protected against flow-induced atherogenesis in vitro and in vivo.","dates":{"publication":"2026/06/26"},"accession":"GSE298183","cross_references":{"GSM":["GSM9009620","GSM9009624","GSM9009623","GSM9009622","GSM9009621","GSM9009617","GSM9009627","GSM9009616","GSM9009626","GSM9009625","GSM9009619","GSM9009618"],"GPL":["16791"],"GSE":["298183"],"taxon":["Homo sapiens"]}}