GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298183/primary200OKOtherHomo sapiensOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298183GEOGSEfalseMETTL3-dependent m6A methylation in atherogenic endothelial inflammation [eCLIP]Atherosclerosis is initiated by endothelial inflammation. Using RNA-seq and eCLIP, we identified METTL3 as a mechanosensitive m6A writer that upregulates NLRP1 and downregulates KLF4 through YTHDF readers. Knockdown of METTL3 abrogated these changes and protected against flow-induced atherogenesis in vitro and in vivo.2026/06/26GSE298183GSM9009620GSM9009624GSM9009623GSM9009622GSM9009621GSM9009617GSM9009627GSM9009616GSM9009626GSM9009625GSM9009619GSM900961816791298183Homo sapiens