{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298331/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298331"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Effect of depletion of p38α and p38β on gene expression in naïve CD8+ T cells","description":"p38 MAPK is activated during CD8+ T cell primary response. p38 activation promotes effector CD8+ T cell terminal differentiation but represses MPEC formation. p38α/β-deficient mice possess a similar number of virus-specific effector CD8+ T cells as wildtype counterparts. Meanwhile p38α/β deletion doesn’t influence the clearance of LCMV although it impairs the cytolytic activity of CD8+ T cells. Loss of p38α/β significantly enhances IL-2-producing Tcm accumulation in mouse spleen with no impact on total memory CD8+ T cell numbers yet. And in line with this, more robust proliferation of memory CD8+ T cells in the secondary response and stronger antigen-specific killing ability in rechallenged mice are resulted from p38α/β deficiency. These results establish a pivotal role for p38α/β in skewing MPEC formation toward SLEC differentiation, as well as in suppressing Tcm formation, and thus affecting the recall response. p38α was reported to be essential in CD8+ T cell maturation, and our mice were observed to be at loss of p38α/β expression in thymic T cells during development. So it's important to see the influence of p38α/β deletion on peripheral naive CD8+ T cells and its potential inborn impact on later events. This would help determining the exact role of p38 signaling in CD8+ T cell immune responses.","dates":{"publication":"2026/06/02"},"accession":"GSE298331","cross_references":{"GSM":["GSM9012104","GSM9012105","GSM9012102","GSM9012103","GSM9012100","GSM9012101","GSM9012098","GSM9012099"],"GPL":["24247"],"GSE":["298331"],"taxon":["Mus musculus"]}}