GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298536/suppl/GSE298536_normalized_counts.xlsxftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298536/primaryOK200TranscriptomicsRattus norvegicusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298536GEOGSEfalsePreservation of Myogenic Tone in Kidney Microvasculature of Dahl Salt-Sensitive Rats. Role of C-C motif chemokine ligand 2Kidney injury mechanisms that develop in salt-sensitive (SS) hypertension are incompletely understood. Using the Dahl SS rat, which is a prominent model of salt-sensitive hypertension and associated kidney injury, loss of function of the pro-inflammatory transcription factor, ETS-1, corrects kidney microvascular autoregulatory dysfunction and injury. C-C motif chemokine ligand 2 (CCL2) is a direct target of ETS-1, so SS rats lacking Ccl2 (termed (SSCcl2 -/-) were therefore examined. Unlike SS rats, SSCcl2 -/- rats did not develop salt-sensitive hypertension, loss of autoregulation of afferent arterioles, or kidney injury. cDNA libraries from renal microvasculature of these rats was sequenced.2026/04/02GSE298536GSM9016430GSM9016431GSM9016420GSM9016421GSM9016432GSM9016433GSM9016422GSM9016423GSM9016424GSM9016425GSM9016414GSM9016426GSM9016415GSM9016427GSM9016416GSM9016428GSM9016417GSM9016429GSM9016418GSM901641920084298536Rattus norvegicus[41833640]