{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298703/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298703"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Tpsb2-CreERT2 system did not alter mast cell viability or development","description":"The selection of an appropriate Cre line is critical for ensuring the accuracy of cell type–specific investigations. We generated a Tpsb2-CreERT2 mouse line that enables precise and efficient labeling of target mast cells, with no detectable off-target recombination or cytotoxic effects, making it a reliable tool for lineage tracing and functional studies. To assess potential Cre-mediated toxicity, we performed transcriptomic analysis of peritoneal mast cells, which revealed no significant alterations in gene expression profiles, further supporting the importance of this model.","dates":{"publication":"2026/03/13"},"accession":"GSE298703","cross_references":{"GSM":["GSM9021236","GSM9021237","GSM9021241","GSM9021240","GSM9021238","GSM9021239"],"GPL":["28330"],"GSE":["298703"],"taxon":["Mus musculus"],"PMID":["[41195564]"]}}