{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Txt":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298752/suppl/filelist.txt"],"Raw":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298752/suppl/GSE298752_RAW.tar"],"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298752/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298752"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"NMuMG PBRM1 ATAC-seq","description":"Mammalian SWI/SNF or BAF are multi-subunit complexes that regulate cell-type specific gene expression by modulating chromatin accessibility, in coordination with transcription factors and other chromatin regulators. PBRM1 is the complex defining subunit of PBAF class of SWI/SNF complexes. It is mutated in ~40% of clear cell renal cell carcinoma cases but also associated with cancer progression and therapy resistance, indicating context-dependent function. We have previously reported that loss of PBRM1 in normal epithelial cells results in a partial Epithelial-to-Mesenchymal Transition (EMT). In this study, we have utilized epigenomic and transcriptomic approaches to understand the mechanistic role of PBRM1 in EMT-regulated gene expression, and its relationship to genome-wide histone modifications.","dates":{"publication":"2026/06/16"},"accession":"GSE298752","cross_references":{"GSM":["GSM9022558","GSM9022569","GSM9022559","GSM9022565","GSM9022554","GSM9022555","GSM9022566","GSM9022567","GSM9022556","GSM9022568","GSM9022557","GSM9022561","GSM9022572","GSM9022573","GSM9022562","GSM9022551","GSM9022574","GSM9022563","GSM9022552","GSM9022564","GSM9022553","GSM9022570","GSM9022571","GSM9022560"],"GPL":["24247"],"GSE":["298752"],"taxon":["Mus musculus"]}}