{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298793/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298793"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Time-restricted feeding blocks kidney fibrosis and damage through diminished CD8+ T cell infiltration in obese mice","description":"Obesity is a major risk factor for chronic kidney disease. Our lab previously showed that a short-term (2 week) time restricted feeding (TRF) intervention in an established model of diet induced obesity (DIO) reduced kidney interstitial fibrosis, increased tubular brush border integrity, and decreased CD3+ T cell numbers. There is very little known about kidney damage and T cell inflammation in obesity. Single cell RNA sequencing was used to determine transcriptomes of CD45+ cells isolated from kidneys.","dates":{"publication":"2026/07/16"},"accession":"GSE298793","cross_references":{"GSM":["GSM9023409","GSM9023406","GSM9023405","GSM9023408","GSM9023407"],"GPL":["24247"],"GSE":["298793"],"taxon":["Mus musculus"]}}