{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298858/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298858"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"ASK1-induces FGF21 expression in the liver","description":"Increasing circulating fibroblast growth factor 21 (FGF21) concentrations may be an appealing strategy to prevent/treat obesity. Herein we identify apoptosis signal regulating kinase 1 (ASK1) as an inducer of hepatic FGF21 production. High fat diet (HFD)-fed liver-specific ASK1 overexpressing mice (ASK1+hep) revealed increased hepatic expression and circulating levels of FGF21.","dates":{"publication":"2026/08/05"},"accession":"GSE298858","cross_references":{"GSM":["GSM9025207","GSM9025208","GSM9025205","GSM9025206","GSM9025214","GSM9025212","GSM9025213","GSM9025210","GSM9025211","GSM9025209"],"GPL":["24247"],"GSE":["298858"],"taxon":["Mus musculus"],"PMID":["[42461584]"]}}