{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298899/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Mus musculus"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298899"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Spatial transcriptomic profiling of ischemia-reperfusion injured mouse kidneys reveals niche-specific metabolic dysfunction","description":"This study presents spatial transcriptomic data from mouse kidneys subjected to ischemia-reperfusion injury to investigate the molecular underpinnings of localized tissue responses. Using high-resolution Stereo-seq spatial transcriptomics, we profiled gene expression across healthy and injured renal microenvironments, focusing on areas surrounding failed repair proximal tubule (FR-PT) cells. Transcriptomic analysis revealed distinct niches characterized by downregulation of oxidative phosphorylation and fatty acid β-oxidation pathways, even in proximal tubule cells considered heatlhy.","dates":{"publication":"2026/08/27"},"accession":"GSE298899","cross_references":{"GSM":["GSM9025645","GSM9025646","GSM9025643","GSM9025644","GSM9025641","GSM9025642","GSM9025640","GSM9025639"],"GPL":["23479"],"GSE":["298899"],"taxon":["Mus musculus"]}}