GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298899/primaryOK200OtherMus musculusOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298899GEOGSEfalseSpatial transcriptomic profiling of ischemia-reperfusion injured mouse kidneys reveals niche-specific metabolic dysfunctionThis study presents spatial transcriptomic data from mouse kidneys subjected to ischemia-reperfusion injury to investigate the molecular underpinnings of localized tissue responses. Using high-resolution Stereo-seq spatial transcriptomics, we profiled gene expression across healthy and injured renal microenvironments, focusing on areas surrounding failed repair proximal tubule (FR-PT) cells. Transcriptomic analysis revealed distinct niches characterized by downregulation of oxidative phosphorylation and fatty acid β-oxidation pathways, even in proximal tubule cells considered heatlhy.2026/08/27GSE298899GSM9025645GSM9025646GSM9025643GSM9025644GSM9025641GSM9025642GSM9025640GSM902563923479298899Mus musculus